Protein and Creatinine, Random Urine

Protein:creatinine ratio in a first-morning or random untimed "spot" urine specimen is recommended testing to ascertain chronic kidney disease.¹ It is also used to evaluate nephrotic syndromes; work up other renal diseases, including malignant hypertension, glomerulonephritis, Goodpasture syndrome, cryoglobulinemia, toxemia of pregnancy, drug nephrotoxicity, and renal tubular lesions; manage myeloma and macroglobulinemia of Waldenström (Bence Jones proteinuria); evaluate hypoproteinemia; tubular proteinurias, including Wilson's disease and Fanconi syndrome. Albumin/Creatinine Ratio, Random Urine is a more sensitive marker of progression and regression of renal disease than urine total protein, especially when urine total protein is <300 mg/g creatinine.

1. Kidney Disease Outcomes Quality Initiative (K/DOQI). K/DOQI clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease.Am J Kidney Dis. 2004 May; 43(5 Suppl 1):S1-290. PubMed 15114537