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Monitor acute-phase proteins associated with inflammatory conditions such as RA and malignant neoplasms.
As an acute-phase protein levels of α1-acid glycoprotein are elevated during infections as well as acute and chronic inflammatory processes (eg, Crohn's disease). In these cases a highly sensitive assessment of the condition of the patient can be obtained by preparing a prognostic index of α1-acid glycoprotein and other parameters such as CRP.1-3 Patients with injuries, burns, or tumors exhibit elevated concentrations. Patients with chronic renal failure are found to have high concentrations of α1-acid glycoprotein, with no major difference reported between dialyzed and nondialyzed patients. Diminished concentrations due to restricted production of α1-acid glycoprotein are found in patients with chronic liver diseases. Low serum concentrations due to increased excretion of the protein are associated with nephritic syndrome.4
1. Pressac M, Vignoli L, Aymard P, Ingenbleek Y. Usefulness of a prognostic inflammatory and nutritional index in pediatric clinical practice. Clin Chem Acta. 1990 Apr 30; 188(2):129-136.
2. Brignola C, Campieri M, Bazzocchi G, Farruggia P, Tragnone A, Lanfranchi GA. A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease. Gastroenterology. 1986 Dec; 91(6):1490-1494.
3. Ingenbleek Y, Carpentier YA. A prognostic inflammatory and nutritional index scoring critically ill patients. Int J Vitam Nutr Res. 1985; 55(1):91-101.
4. Routledge PA. Clinical relevance of alpha 1 acid glycoprotein in health and disease. Prog Clin Biol Res. 1989; 300:185-198.
