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Use: To access patients for immunity to Hepatitis A Virus (HAV) and Hepatitis B Virus (HBV). Detectable total anti-HAV antibody indicates immunity to HAV infection. Although usually not sensitive enough to detect the low level of protective antibody after vaccination, anti-HAV tests also might be positive after hepatitis A vaccination. The detection of anti-HBs antibodies in the absence of anti-HBc antibodies indicates immunity to HBV infection due to vaccination. The detection of both anti-HBs and anti-HBc antibodies indicates immunity due to natural infection.
Limitations: The assays in this panel have not been FDA cleared or approved for the screening of blood or plasma donors. Assay performance characteristics have not been established for immunocompromised or immunosuppressed patients, coed blood, or patients less than 2 years of age.
Methodology: Immunochemiluminometric assay (ICMA)
