Pay with Crypto and get 10% off your order!
Diagnosis of hyperthyroidism and Graves' disease.
Thyrotropin-receptor antibody is an autoantibody to the thyroid cell receptor for thyroid-stimulating hormone. It can be demonstrated in 90% of patients with Graves' disease, and is the cause of the hyperthyroidism of that condition. The characterization of TRA resolved much confusion about long-acting thyroid stimulator (LATS) and LATS protector, which are both, in fact, thyroid-stimulating autoantibodies which simply behaved differently in animal test systems. These antibodies are present in 50% of euthyroid Graves' disease as well as hyperthyroid patients. They play a major role in the pathogenesis of Graves' disease. Detection of these antibodies is useful in prediction of neonatal hyperthyroidism and prediction of relapse of hyperthyroidism.
Colvin RB, Bhan AK, McCluskey RT, eds. Diagnostic Immunopathology. New York, NY: Raven Press;1988.
Gupta MK. Recent advances in laboratory tests for autoantibodies to thyrotropin receptor protein in Graves' disease. Clin Lab Med. 1988 Jun; 8(2):303-323 (review). PubMed 3284698
Gupta MK. Thyrotropin receptor antibodies: Advances and importance of detection techniques in thyroid disease. Clin Biochem. 1992 Jun; 25(3):193-199. PubMed 1633635
McKenzie JM, Zakarija M. Clinical review 3: The clinical use of thyrotropin receptor antibody measurements. J Clin Endocrinol Metab. 1989 Dec; 69(6):1093-1096. PubMed 2685006
Morris JC 3rd, Hay ID, Nelson RE, Jiang NS. Clinical utility of thyrotropin-receptor antibody assays: Comparison of radioreceptor and bioassay methods. Mayo Clin Proc. 1988 Jul; 63(7):707-717. PubMed 2898572
Nakamura RM, Binder WL. Current concepts and diagnostic evaluation of autoimmune disease. Arch Pathol Lab Med. 1988 Sep; 112(9):869-877 (review). PubMed 3046557
