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Determine creatinuria; increased urine creatine values may be obtained from diseases that reduce muscle mass, including fasting, muscular dystrophy, poliomyelitis, atrophy, inflammatory destructive muscle disease as polymyositis, hyperthyroidism, as well as corticosteroid induced myopathy.
Creatine is endogenously synthesized in the kidney, liver, and pancreas. It is transported in blood to other organs such as muscle and brain, where it is phosphorylated to phosphocreatine. Interconversion of phosphocreatine and creatine is a unique feature of the metabolic processes of muscle contraction; some of the free creatine in muscle spontaneously converts to creatinine, its anhydride. Between 1% and 2% of muscle creatine is converted to creatinine daily.
