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Serological non-treponema-specific test for syphilis used to screen for syphilis infection and to determine the effectiveness of treatment.
False-positive reactions occur due to pregnancy, drug addiction, collagen vascular disease, and advanced age. In addition, false-positive results have been noted in the presence of numerous nonsyphilis infectious diseases, including HCV infection,1 inflammatory states, or in individuals who have been recently vaccinated against influenza virus.
1. Thomas DL, Rompalo AM, Zenilman J, Hoover D, Hook EW 3rd, Quinn TC. Association of hepatitis C virus infection with false-positive tests for syphilis. J Infect Dis. 1994 Dec; 170(6):1579-1581. PubMed 7527828
