Human Papillomavirus (HPV) High- and Low-risk DNA Detection

This assay aids in the diagnosis of sexually-transmitted HPV infection and is used for the triage of patients with an ASC-US Pap test result. The test provides a qualitative molecular detection of 18 different human papillomavirus types in cervical specimens. The HPV test distinguishes between two HPV DNA groups without differentiation of the individual type:

- Low-risk HPV types: 6, 11, 42, 43, 44

- High-risk types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68

A negative result does not exclude the possibility of an HPV infection since very low levels of infection or sampling error may produce a false-negative result.

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Manos MM, Kinney WK, Hurley LB, et al. Identifying women with cervical neoplasia: Using human papillomavirus DNA testing for equivocal Papanicolaou results. JAMA. 1999 May 5; 281(17):1605-1610. PubMed 10235153

Schiffman M, Herrero R, Hildesheim A, et al. HPV DNA testing in cervical cancer screening: Results from women in a high-risk province in Costa Rica. JAMA. 2000 Jan 5; 283(1):87-93. PubMed 10632285