Aid in the diagnosis of acute or chronic hepatitis B virus (HBV) infection and in the determination of the clinical status of HBV infected individuals in conjunction with other HBV serological markers. Aid in differential diagnosis of hepatitis. The presence of anti-HBc total antibody indicates previous or ongoing infection with HBV in an undefined time frame.
AuBuchon JP, Sandler SG, Fang CT, Dodd RY. American Red Cross experience with routine testing for hepatitis B core antibody. Transfusion. 1989 Mar-Apr; 29(3):230-232. PubMed 2493695
Chambers LA, Popovsky MA. Decrease in reported post-transfusion hepatitis. Contributions of donor screening for alanine aminotransferase and antibodies to hepatitis B core antigen and changes in the general population. Arch Intern Med. 1991 Dec; 151(12):2445-2448. PubMed 1747001
Edwards MS. Hepatitis B serology—help in interpretation. Pediatr Clin North Am. 1988 Jun; 35(3):503-515 (review). PubMed 3287312
Gupta S, Govindarajan S, Fong TL, Redeker AG. Spontaneous reactivation in chronic hepatitis B: patterns and natural history. J Clin Gastroenterol. 1990 Oct; 12(5):562-568. PubMed 2230000
Lee HS, Vyas GN. Diagnosis of viral hepatitis. Clin Lab Med. 1987 Dec; 7(4):741-757 (review). PubMed 3319367
Mushahwar IK, Dienstag JL, Polesky HF, McGrath LC, Decker RH, Overby LR. Interpretation of various serological profiles of hepatitis B virus infection. Am J Clin Pathol. 1981 Dec; 76(6):773-777. PubMed 7315794