Alpha-2-Antiplasmin

The most important inhibitor to plasmin, a2-antiplasmin prevents plasmin action on fibrin during fibrinolysis. Decreased levels may lead to easy bruising, epistaxis, hematuria, menorrhagia, hemarthrosis, and bleeding after trauma or surgery.

Congenital deficiency is rare. Acquired deficiency occurs with systemic thrombolytic therapy, acute promyelocytic leukemia, and nephrotic syndrome.

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